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Toshiro Migita Selected Research

ATP Citrate (pro-S)-Lyase (Citrate Synthase, ATP)

3/2016Polyamine regulating protein antizyme binds to ATP citrate lyase to accelerate acetyl-CoA production in cancer cells.
7/2014Inhibition of ATP citrate lyase induces triglyceride accumulation with altered fatty acid composition in cancer cells.
5/2013Inhibition of ATP citrate lyase induces an anticancer effect via reactive oxygen species: AMPK as a predictive biomarker for therapeutic impact.
10/2008ATP citrate lyase: activation and therapeutic implications in non-small cell lung cancer.

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Toshiro Migita Research Topics

Disease

22Neoplasms (Cancer)
01/2021 - 02/2002
8Prostatic Neoplasms (Prostate Cancer)
10/2017 - 01/2004
4Stomach Neoplasms (Stomach Cancer)
01/2021 - 10/2009
3Residual Neoplasm
03/2020 - 04/2002
2Urinary Bladder Neoplasms (Bladder Cancer)
02/2017 - 04/2002
2Carcinogenesis
09/2014 - 04/2009
2Adenocarcinoma
08/2013 - 04/2009
2Adenocarcinoma of Lung
04/2010 - 10/2008
1Non-Muscle Invasive Bladder Neoplasms
02/2017
146,XY Disorder of Sex Development (Male Pseudohermaphroditism)
11/2016
1Neoplasm Metastasis (Metastasis)
02/2009
1Lung Neoplasms (Lung Cancer)
10/2008
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
10/2008
1Renal Cell Carcinoma (Grawitz Tumor)
07/2008
1Acidosis
01/2004
1Hypoxia (Hypoxemia)
07/2003
1Kidney Neoplasms (Kidney Cancer)
07/2003
1Disease Progression
04/2002

Drug/Important Bio-Agent (IBA)

6EnzymesIBA
07/2014 - 01/2004
4ATP Citrate (pro-S)-Lyase (Citrate Synthase, ATP)IBA
03/2016 - 10/2008
4Proteins (Proteins, Gene)FDA Link
03/2016 - 07/2003
4Fatty Acid Synthases (Fatty Acid Synthase)IBA
04/2009 - 01/2004
3Pharmaceutical PreparationsIBA
03/2020 - 04/2002
3AndrogensIBA
10/2017 - 03/2004
3Cadherins (E-Cadherin)IBA
02/2017 - 07/2008
3Messenger RNA (mRNA)IBA
10/2009 - 04/2002
2Hormones (Hormone)IBA
10/2017 - 11/2012
2CholesterolIBA
11/2016 - 03/2016
2Fatty Acids (Saturated Fatty Acids)IBA
07/2014 - 01/2004
1Monoclonal AntibodiesIBA
01/2021
1RamucirumabIBA
01/2021
1Therapeutic UsesIBA
01/2021
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2021
1Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA
01/2021
1Fluorouracil (Carac)FDA LinkGeneric
03/2020
1Irinotecan (Camptosar)FDA LinkGeneric
11/2019
1ErbB Receptors (EGF Receptor)IBA
11/2019
1Transforming Growth Factors (Transforming Growth Factor)IBA
02/2017
1Carrier Proteins (Binding Protein)IBA
01/2017
1TankyrasesIBA
01/2017
1LipidsIBA
11/2016
1Cholesterol Side-Chain Cleavage Enzyme (CYP11A1)IBA
11/2016
1steroidogenic acute regulatory proteinIBA
11/2016
1Steroidogenic Factor 1IBA
11/2016
1PolyaminesIBA
03/2016
1Acetyl Coenzyme A (Acetyl-CoA)IBA
03/2016
1Angiogenic ProteinsIBA
02/2016
1Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA
09/2014
1Endoplasmic Reticulum Chaperone BiPIBA
09/2014
1Triglycerides (Triacylglycerol)IBA
07/2014
1Telomerase (Telomerase Reverse Transcriptase)IBA
08/2013
1Biomarkers (Surrogate Marker)IBA
04/2010
1Insulin-Like Growth Factor Binding Protein 2IBA
04/2010
1Caspase 3 (Caspase-3)IBA
04/2010
1Factor XII (Hageman Factor)IBA
10/2009
1AgarIBA
04/2009
1Uridine Triphosphate (UTP)IBA
04/2009
1DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA
04/2009
1Androgen Receptors (Androgen Receptor)IBA
04/2009
1beta CateninIBA
12/2008
1Phosphotransferases (Kinase)IBA
10/2008
1isopeptidaseIBA
03/2004
1Glucose (Dextrose)FDA LinkGeneric
01/2004
1Adenosine Triphosphate (ATP)IBA
01/2004
1Nonesterified Fatty Acids (NEFA)IBA
01/2004
1Oxygen (Dioxygen)IBA
01/2004
1lipid mobilizing substanceIBA
01/2004
1Lactic Acid (Lactate)FDA LinkGeneric
01/2004
1Biological ProductsIBA
01/2004
1NickelIBA
07/2003
1Ceruloplasmin (Ferroxidase)IBA
07/2003
1Casein Kinase I (Casein Kinase 1)IBA
07/2003
1thymosin beta(4)IBA
07/2003
1Von Hippel-Lindau Tumor Suppressor ProteinIBA
07/2003
1Serum Amyloid A Protein (Serum Amyloid A)IBA
07/2003
1OsteopontinIBA
07/2003
1Heat-Shock Proteins (Heat-Shock Protein)IBA
07/2003
1Cysteine (L-Cysteine)FDA Link
07/2003
1Multidrug Resistance-Associated ProteinsIBA
04/2002
1RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA
04/2002
1Doxorubicin (Adriamycin)FDA LinkGeneric
04/2002
1Member 1 Subfamily B ATP Binding Cassette TransporterIBA
04/2002
1Succinate Dehydrogenase (Fumarate Reductase)IBA
04/2002
1Antineoplastic Agents (Antineoplastics)IBA
04/2002
1multidrug resistance-associated protein 1IBA
04/2002
1Cyclin D1IBA
02/2002
1Cyclin AIBA
02/2002

Therapy/Procedure

2Therapeutics
01/2021 - 09/2014
2Castration
10/2017 - 11/2012
2Nephrectomy
02/2009 - 04/2004
1Aftercare (After-Treatment)
11/2019
1Transplantation
12/2008
1Drug Therapy (Chemotherapy)
04/2002